Honestly this is the part I hate most about Clojure. The tooling is always so convoluted to setup and by the time you start your next project something has changed again, requiring more changes which might break your tool chain. ClojureScript is especially guilty of this right now with all the recent repl changes.

I appreciate the The CS team trying to work with 3rd party repl developers right now, but it doesn't seem to be helping much. It's pushed me back to simple gulp based es6 dev using ramda, rxjs, immutablejs, etc - basically the parts of clojurescript I like. The only thing I sort of miss from Clojure are macros and homoiconicity - it sure is nice to look so uniform, but the tooling just drives me away.