I had a severe negative reaction to lithium, along with risperdal and abilify. I've liked Seroquel, which surprised me after all the others I tried were awful. Someone else might say the reverse (Seroquel was awful but those other drugs were better).

The important lesson is that, if a treatment isn't working for you, then you should try something else. My first psychiatrist was extremely hostile to the idea of me switching drugs, so I concluded that all psychiatrists were useless. In retrospect he was wrong, because switching to Seroquel was a good idea for me, and I wouldn't have tried it if I didn't fire him.