I found a writeup [1] on how to write your own virtualenv. It doesn't look like there's much overhead there.
I suppose one could justify not using virtualenv if they're on a system with limited resources or network access. I've known people who spent hours building a compiling python 2.7 from source on embedded systems because they rolled their own distro, and in that situation it would make sense to not want to mess with virtualenv if you just spent hours getting pip working.
1: https://www.recurse.com/blog/14-there-is-no-magic-virtualenv...
With this you just have one tool, and it's just easier for me to understand what's going on compared with virtualenv.
I'm not too sure that this would end up being any easier, but maybe...
[1] http://streetsign.org.uk/ [2] https://bitbucket.org/dfairhead/streetsign-server/src/5b359a...