What I love doing - re-training myself to use a PC-101 keyboard after a week or some days using the rMBP on the road .. nothing funks up my flow more (in a good way) than going from the hotkeys of OSX to those of a moderately standard fvwm-based Linux desktop, and having a full keyboard switch-up to boot. I kind of think such small experiences are good for you, so I delight in it happening when it does ..
However, it terrifies me to use my friends' Dell and Lenovo machines, the key placement is often perplexing. I somehow think the layout is intended to bond the user to the platform, though, and few companies apply that as succinctly than Apple.