We serve millions of requests per day and have some slow responses (75+ ms) but on any given day our servers handle 175 requests per second without breaking a sweat. =/
So for example if an app does something bad like performing a full table scan on every request against a 300 million collection, so every request to that backend is timing out at 30 seconds, and there are thousands of them per second, well -- pretty soon your fixed pool will be full of requests timing out to that backend.
Many organizations scale out too soon or for the wrong reasons, and some just have ineffecient database queries and other things that result in bad request times that they could also optimize -- which helps the user regardless of scale with faster page loads.