There are many different paths by which user can access the contents of your web app. For high performance apps, you'll want to optimize this process. Here are two suggestions:
- Use a CDN to serve static content without the need to serve the content out of the origin server every request.
- Create instances of your application in multiple regions. The shortest path to your web app varies based on where the user is in the world. Multiple regions can minimize the latency introduced via the hops s/he must make.