Even on the backend, in the end you have to run native machine instructions. HTML/JS/CSS substitute for that on the front end. Of course, x86_64 may be a better compile target, but the advantage of the existing languages over any new system is that there has been a lot of work that has already gone into making them fast, backwards compatibility, all browsers already implement them, and there are a lot of things that can target them now.
See also: https://www.destroyallsoftware.com/talks/the-birth-and-death...