I did this before I had a family. Now, it's the first flight out. Sometimes I'll fly in a day early to get over jet lag, but that's usually working in a hotel room.
Most of my business trips are airport/hotel/work/airport, but occasionally, I'll use accumulated frequent-flier miles to have my wife join me and extend the trip. We've done Australia twice this way. When you're that far away, it makes a lot of sense to take advantage of it!
You need to plan it I spent a month for work in Edinburgh once and didn't come back so I had 4 weekend breaks staying in the Balmoral (most expensive hotel in town).
Unfortunately my plan to do the same for the Edinburgh fringe did not work out