I feel like this sentiment is very common, but is implicitly stating that all of the other things, family, friends, personal health etc... are not games - when I don't see why that would be the case. Nothing distinguishes those things for me.
Creating new products, like software that gives people better productivity, or hardware that helps people achieve physical fitness goals, or systems that make getting clean water cheaper - those are life changing to a lot of people, sometimes even millions. The typical response to this is "yea but most people make junk" to which I say, telling junk from non-junk is an exercise in futility.
We wouldn't be quoting Paul Buchheit or talking about Dave Sandberg if they hadn't sacrificed some of those relationships, or health for the products and platforms that we know them for. And that's the real point - legacy. Someone's legacy is not the relationships they had personally, just look at the miserable relationship failures of Steve Jobs, but their impact on bringing their vision and impact on groups outside of their circle.
Winning in my opinion then, is having an (hopefully positive) impact on those outside of your inner circle, not within it. And the larger the impact, the bigger the win.