It might look kind of cool at first, but it puts additional barriers in between the user and actually doing something useful like entering data in a form, booking a flight, etc.

For example, if I haven't been to the site before, I might have to explore the interface a bit before I get to the part of the interface I want. Clicking on those tiles makes things shift and bounce around, the content portion of the screen constantly moves left to right.

Way too much difficulty for doing something so simple.

Designs should be visually appeasing, but not at the expense of ease of use or ease of understanding.