http://isabelle.in.tum.de/dist/library/HOL/HOL/Real.html
This is the classical way (and similar to HOL Light or HOL4). AFAIK in Coq the standard way is to introduce the reals axiomatically.
The bottom theories in http://isabelle.in.tum.de/dist/library/HOL/HOL/ are all about classical real analysis, based on topology and real-normed vector spaces.