Obviously there was a slave trade prior to the invention of the cotton gin (1793, well after the Declaration of Independence (US)), but the significant growth of the slave trade in the US occurred after the invention of the cotton gin (which lead to the massive growth of the cotton trade; especially in the US southern states as they had a better climate for cotton growth).
I know it's something certainly not unique to the american south and it's still going on today. I guess the contrast to the declaration of independence and slavery is so telling. Most other slavery occurs under the watch of despots.
Evsey Domar wrote a famous paper in 1970, arguing that slavery/serfdom may be instituted when there is a lot of available land and few available workers, citing episodes in Europe in the Middle Ages, Russia's eastward expansion, and the US South.
The cotton gin changed that, making large-scale cotton production profitable and drastically increasing the demand for slaves (and thus creating an incentive to find justifications for and defenses of the practice of slavery).
Alexis de Tocqueville famously noted the differences in industrial development between slave and free states. But Southerners (at least those with slaves) generally defended slavery as an institution and equated the plantation system with the "Southern way of life". And, by all accounts, even if they hadn't, white supremacism was so deep and broad it's unlikely any kind of economic concerns would have been able to overcome it in any policy debate.
West Africans had resistance to malaria (including sickle cell anemia) and the Southern landowner with slaves made more money than the landowner with European indentured servants where anywhere from 40-70% would be dead or otherwise not working due to disease.