My favourite realization of this: Frank McSherry shows how simplicity and a few optimisations can win out on graph analysis in his COST work. In his first post[1], he shows how to beat a cluster of machines with a laptop. In his second post[2], he applies even more optimizations, both space and speed, to process the largest publicly available graph dataset - terabyte sized with over a hundred billion edges - all on his laptop's SSD.
[1]: http://www.frankmcsherry.org/graph/scalability/cost/2015/01/...
[2]: http://www.frankmcsherry.org/graph/scalability/cost/2015/02/...