Yes. Yes. Yes! Omg. Yes.
The worst I have seen was a team of several hundred people who, on $200 half-broken laptops, were running - in parallel - 500MB Excel files for hours every day, which basically did a few linear operations on about 30 variables, before joining the results in a superfile itself taking up to 20 minutes just to open on a gaming-specced desktop.
In another case, I broke down an Excel model with over 50 tabs and discovered that there were only 2 input variables. Unfortunately the CFO of that business decided to go for the ostrich strategy (after all the monster model impressed investors).
Every business I have ever worked in had some convoluted, cumbersome, buggy, opaque, human-dependent Excel processes. My co-founder and I finance our startup replacing these with tight scripts running on AWS (amongst other things) - it's low hanging fruit. We approach these things as a black box, figure out desired behaviour, and rebuild from scratch.
Excel wins all the time because it's a UI that managers are familiar with, and they are often either the consumers, or want to audit your data processes. It's got a LOT of tooling that lets non-technical users do things they shouldn't.
If you thought Python Pandas was an improvement, try learning about the relational model and how to use a decent relational database (I recommend PostgreSQL, whose error messages will teach you a few things and which has a saner type system where you CAN compare two different integer types without getting NULL). You'd be amazed how far you can go with just SQL.
You should also do so from a UNIX OS, and from the command line (using pg, editing a file then running \f blah.sql). It will take you a few hours of pain but will be worth it in added productivity and transparency over any point and click alternatives.
What you're touching on is the power of abstraction, functional vs imperative programming, and particularly how proving programs can be enormously productive. SQL is powerful for this because it is declarative and very close to mathematics (Codd brought set theory to databases).
The next steps are category and type theory and then the Haskell/Mercury/Idris/Coq rabbit hole... an unpopular one because, as someone once told me, "businesses are resilient to application errors"...