One thing I __really__ miss from working in lisp is the idea that I can reload things in the repl. In Python, once I've imported something, I can't really redefine it without pasting in the definition, which makes iterating on a class definition much harder. In Lisp, I can hit a key in my editor and the running REPL gets the new definition, and I can start working with it (or rewriting tests, etc).
The power of the REPL in lisp is __amazing__. I love me some IPython (it's awesome), but there just isn't the same tight integration between that and a running system. The "default" Python likely has all the tools you need to do that, but it just isn't presented as the Way you Do It.
Django's auto-reload when code changes is an example of this. The trouble is, I can't get to a REPL easily within that, without invoking ipdb. I don't know how to integrate my editor with the Python process in a similar way, etc.
All that said, I still love coding in Python. Hy makes me excited, but then I just started writing python-with-parens and wasn't sure what I had gained. :)
0: I'm sure there is someone who can give a counterexample, but I cannot thnk of any.