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A third (reboot) is already planned, you mean you want a forth?!

One where he starts as an actual spider and gets bitten by a radioactive man, just to give us something different forth time around.

Just like "The Spider", a villain in Rat-Man: http://en.wikipedia.org/wiki/Rat-Man_%28comics%29#The_Spider It can't climb walls, but has acquired human personality traits: selfishness, greed and cruelty.