Ardour looks pretty nice actually, but I haven't used it myself. Same goes for Reaper and Presonus Studio One.
In the end, in my experience, it comes down to a few things:
- stability and available support for problems
- ability to share native sessions w/ other users (as opposed to just stems)
- support for hardware (audio i/o and controllers, including mixing surfaces)
- ease of use - so the interface and process doesn't get in the way of the creative process
I am not necessarily a fan of ridiculous skeuomorphism in things like plugins, but at the same time a big knob or fader on the screen makes a lot more (and a lot quicker) sense to me than a little box w/ a hex value in it. I think the advent of touch screens in pro installations reinforces this - see Slate's Raven controllers, which are becoming very popular now - http://www.slateproaudio.com/products/raven-mtx/
In the end though this is just me - more power to anyone making good music anyway they can.