Humans have no natural predators. Zero. Think about that. Anything that may have once threatened us, we've out organized, out planned, and out thought on the way towards global dominance. Even superficially similar co-inhabitant species like Neanderthal could not survive in a world with Humans. Today, only microscopic creatures threaten us, and we once again organize, plan and think about ways to defeat these creatures.
Even with stone-aged levels of technology we spread to every corner of the world, in every known climate and ecology, in large numbers, and thrived. The only thing that is dangerous to humans is other humans. And we've even arrived at the point that, with no considerable effort at all, we're capable of wiping out every living thing that inhabits the surface of a world.
Despite having poor biting power, diminished canines, running (poorly) on our heels, lower than average strength and no claws. We are the the most dangerous creature in the known universe.