Same thing applies to any content type. Images, CSS, video support, etc. Why pick on JS specifically?
If the JavaScript fails to load and you were using it to significantly alter the content on your page, for example loading a news article asynchronously, the entire page fails to load.
I don't mean to pick on this app in particular (I actually think it's really cool and I plan on using it and learning from it), but take a look at what happens to http://hswolff.github.io/hn-ng2/ when you switch off JavaScript--it's completely unusable. Now try switching off JavaScript on Hacker News--all the links and comments are still there.
Worse. Half the time the content is sent synchronously in the initial HTML, but keep hidden until a JS script has its way with it. Looking at you Markdown.js.