> The same mechanic told me that some 6-cyl Toyota engines lose 42% of efficiency on 10% ethanol.
He's off by a magnitude. E10 has about 97% energy density as 100% gasoline (http://www.afdc.energy.gov/fuels/fuel_comparison_chart.pdf)
A 42% loss would be huge. A 30 MPG Toyota would get about 18-19 MPG.