So it's not strictly accessible.
If you can find it, run the 100% pure stuff in your lawn equipment unless it specifically says it can run on E10. The E10 absolutely destroys the old rubber lines and clogs up carburetors.
Though I generally have tried to move away from 2 cycle tools to LiPo electric ones where feasible. My electric push power works really well, and I maintain a little under 2 acres of grass.
He's off by a magnitude. E10 has about 97% energy density as 100% gasoline (http://www.afdc.energy.gov/fuels/fuel_comparison_chart.pdf)
A 42% loss would be huge. A 30 MPG Toyota would get about 18-19 MPG.
It just isn't possible to lose 42% from running E10. You won't even lose that much efficiency from running low octane fuel in an engine that requires high octane.
Are you getting E10 confused with E85? E85 is a whole different beast and will ruin a car not designed to run on it.