I've done a lot of WebRTC work -- we currently use Google Hangouts everywhere at Stack Exchange for internal team communication, but the 15 person cap hurts some bigger all-hands calls or our weekly remote parties. I don't think the hardest part of WebRTC is transcoding or TURN servers (what Twilio seems to be offering), multiplexing is where all the complexity comes from.
It's very easy to set up a video chat interface via WebRTC small-scale, and good on Twilio for focusing on making it easier to integrate mobile clients too, but I can't wait until someone (most likely the Talky.io team seeing how their betas are going) makes it a bit easier to have large N connections (right now on Hangouts N is 15, on my own stack N is around 10).