It is a discussion initiative for the next era of JavaScript development using the latest technologies available. As JavaScript is everywhere now, there are still differences in environments and different methodologies used that make writing code that should be working everywhere, really hard. Just take a look at how many manifest.jsons are in every package and you'll know what I mean. And it doesn't stop there.
I believe we should agree on a minimum level of how things should work, otherwise this is only going to get worse over time. The issues in the repo are used for the discussion of various topics, I started one[0], I'd love to hear everyone's thoughts on this.
[0]: https://github.com/isojs/isojs/issues/1