For the Waterfox/Firefox users, there are various unload tab add-ons, which aim at reducing the unloaded tabs' memory footprint to a minimum. They generally lag behind the latest version in compatibility somewhat, but use the Session Manager add-on to preserve tab state and any crashes won't take out all the effort you put into organizing open tabs. I currently use UnloadTab [1].
People who organize their browser activity around hundreds of tabs must not be a large use case population, because this organizational method seems quite popular among this vocal set of users but not popular among the browser designers/architects/developers.
These days I'm transitioning to organizing my links inline into my organizing that I perform inside my emacs Org mode files. Instead of a massive list of links, I inline the link as part of the note-taking for a particular task/note/appt. The Org mode grab link function for Macs make it easier to grab a link from Waterfox/Firefox, saving some copy-paste context-switching time. If I could insert a current tab's URL into my Org mode file-and-outline structure, iswitch-style from within the browser, save the changes to the Org mode file, then close the tab, that would be quite an efficiency boost.
[1] https://addons.mozilla.org/en-us/firefox/addon/unloadtab/