I respectfully disagree. I use a 27" external monitor with a MacBook Pro as my keyboard and mouse. I find external mice and keyboards too wide. It's been a while since I used a full sized keyboard but I find they make my right shoulder ache.
Since I can touch type I don't really miss the keypad at all. In fact I remap Caps Lock to Ctrl and use Ctrl-h, Ctrl-m, Ctrl-i (in Colemak) so that I don't have to reach for backspace, return and tab. That saves my right wrist, which seems to be a bit weak.
Then again I spend a lot of time in a tmux window with short cuts to move about, so that might be why it works for me.
[Updates for grammar]