Their killer use case is moving heavy stuff to inaccessible areas. Wind turbines being the flavour of the moment. They combine the long distance capability of a plane, the hovering of a helicopter and the lift capacity of a crane...
However, once the 160 tonne payload has been dropped, the ship either needs to take on 160 tonnes of ballast or jettison helium (not an option since it's so expensive). The Cargolifter idea was to just pump up water if I remember correctly, but for land-based tasks that meant being met by ten tanker lorries at the drop site, thus negating all the benefits and meaning you might as well stick the cargo straight on those trucks.
I'd love to see it work out, but so far these projects have been nothing but a wipeout for investors. Coincidentally back in 2006 I worked a couple of desks over from people managing the liquidation of Skycat, which was basically the same thing, also built at Cardington. It may even have been the same team.