However I still wonder - is bytecode the only way to go about this? Every compile-to-JS language I've used has either been sugar over JS or had JS's semantics/syntax seeping through the cracks...what if the base language was a Lisp? There's a big difference between being bound to the semantics of a language like JS or dart and those of Lisp.
I have no doubt that a new VM would be a herculean undertaking and be riddled with all sorts of problems, but I remain unconvinced that it wouldn't pay off in the end. Maybe I'm being naive, but if what we're doing now really is as good as it gets then it seems either I'm much more ignorant to the issues at play than I thought or this hole is significantly deeper than even I imagined.