The 601 was comparable to the multiple-issue scoreboard architectures used in 1960s supercomputers, such as the CDC 6600, the IBM 7030, and the UNIVAC LARC. The 601 (I think) was a scoreboard machine, not a rename and retire machine.

A scoreboard machine blocks when two instructions use the same register. A rename and retire machine (most modern out-of-order execution CPUs) can map the same program-visible register to multiple machine registers and parallelize even when there's a register reuse, as long as there isn't real data dependency. The "retirement unit" at the end of the pipeline sorts out conflicts.

Scoreboard machines need lots of program-visible registers, and compilers which avoid reusing them when there are registers free. How much of that needs to be done varies with the CPU implementation, which is why compilers for MIPS machines had flags to optimize compilation for each MIPS implementation. This was a huge pain for software distribution. One problem with having lots of registers visible to the program is that context switches require saving all of them to RAM, which is a drag on CPU dispatching.