The problem with Lisp-like DSL construction, is that the interface doesn't play well with many populations of domain experts. Even Smalltalk, with its syntax designed to be usable by children can fulfill the technical side of constructing DSLs easily, but still leaves something to be desired when it comes to domain expert use. (Various Smalltalks had their rough equivalent to #lang.)
(I know there is at least one Ruby based DSL which made some inroads to mobile device software testing.)
Basically, DSLs tend to only get used by experts who are already programmers or otherwise technically disposed. Maybe we're getting to the point where rudimentary coding is just going to be a new kind of literacy?