Sustainable competitive advantage - excellent phrase. It covers a wider range of possibilities than are implied by rocket science.
One of the reasons I originally posted the question is that I'm particularly interested in one of the ideas that YC mentioned in the startup ideas that YC would like to fund, enterprise software 2.0 (http://ycombinator.com/ideas.html see number 5).
My experience in that space is that there are a number of companies that are generating huge revenues using software that could be improved via the "build a better mousetrap" methodology. But basically none of that space requires rocket science, unless you include the ability you have as a startup to use more powerful languages and tools than your standard corporate behemoth.
Now, that said, using more powerful tools might free you up to innovate in ways other companies can't, similar to how PG has touted Lisp as a big strength for Viaweb . . .