Boston's startup scene is dominated by MBAs who think hackers are cogs you put red bull in to get code out and technical cofounders are only worth 5% of the company. I think YC actually has done a lot to change this in the last few years as someone who interacts with the scene often, though these MBAs will never go away.
Sounds like my job! I'd love to see more YC activity back in their home town to try to fix this. However, the YC programs seem to have a tremendous amount of inertia so it's hard to see how they could run a program similarly-successful on the east coast despite starting out here.
The founder of the first start-up I worked for around 2006 told me that most of the money and network was centered around Harvard. It was difficult to get funding as a non-Harvard alum.