Knowledge is an idea/concept that you understand on a deep level and is interconnected with other ideas. You can't easily forget it.
Information is an idea/concept that you don't really understand on a deep level or can easily can interconnect with other ideas. Assuming that our memory is full most of the time (unless you are making some kind of defragmentation aka meditation/relaxation) to get new information your brain must make space in your memory first. Lots of information is continually being lost.
IMHO, empirically, each person has:
-"ROM" (memory to store knowledge, normally increasing along your life).
-"RAM" (memory to store novelty, normally decreasing along your life).
Probably genetics provide minimum and maximum sizes that these 2 memory types can ever reach.