The one which had me sad recently is the soundtrack to the game Bastion: http://supergiantgames.bandcamp.com/album/bastion-original-s...
It's noticeable on almost every track basically as soon as the drums kick in. (About ten seconds into "A Proper Story", for example). It's depressing that this has occurred even on a piece of indie content for which so much care has otherwise been taken— Darren Korb was the sound designer for the game and gave a terrific presentation at GDC 2012.