Considering how many great artists "die before their time" and combining that with his own words, I see that as difficult to reconcile. It's one thing to admit to doing something for a paycheck, and there's pride to be had in honest work. To me it's dishonest to claim art is the primary driver and then, well, give up on doing art. What part of that do you disagree with?
Edit:
I never said I expected more Calvin and Hobbes, and if you think you're putting something forward with that quote I don't already know, you're wrong.
He had a platform to produce all kinds of other creative, influential, or interesting art, and he chose not to do anything. Well, maybe he did and it's all up in his attic. What good does an attic full of art do for the world?