Project Jigsaw which will be a big part of Java 9 aims to make the JVM more modular which will reduce the memory footprint substantially. Personally I would like to see a version of Clojure that targets this JVM specifically and abandons backwards compatibility.
Leaving the JVM means you abandon the decade of libraries many of which you simply can't get on any other platform (in particular for the enterprise). Given that Clojure has been gaining a lot of ground in these large companies it seems like a missed opportunity.