Indeed! We love this community [1]. We started 20n with DARPA's help, in part to gather more steam around the accuracy of software predictions tools within synthetic biology. You seem to have worked on these tools, and so must know the pain of convincing wet-lab scientists to follow up on the sw predictions.
Paracetamol, both for academics and to pharma, was a non-biosynthesizable molecule. But once we had the prediction, we were able to go to the lab to construct the microbe pretty easily.
In the end, the tool is the start of the process. We are investing significant resources in constructing the microbes. Over the coarse of the next two year, hopefully you will find some novel molecules in the ones we move to bioproduction.
[1] Have to! We are part of it. :) We know most of them, and they probably know us.