There might be additional market forces that make a microbial fermentation attractive: e.g., in the case of the anti-malarial drug artemisinin, fluctuation in supply of the plant Artemisia annua, the price of the drug varied between $120-$1200/kg, and Amyris and Sanofi moved it to yeast based production for creating a steady supply [2]. That route was critical for the supply of the drug to African countries.
For many of the requests we get, chemical synthesis is not economically feasible to take the chemical to market, and bioproduction might be the only route. The fact that we suggest routes that work well for the planet is a good side-effect. :)
[1] http://en.wikipedia.org/wiki/Paracetamol#Synthesis
[2] http://en.wikipedia.org/wiki/Artemisinin#Synthesis_in_engine...