One of the things I didn't realize at first was the degree to which Relay/GraphQL appear to effectively replace a lot of Flux: http://facebook.github.io/react/blog/2015/02/20/introducing-...
Learning Flux sort of seems like learning how to drive stick shift on an '97 Civic while we wait for the new Tesla to arrive - useful, also a bit annoying. A central store architecture does seem a better match to what Relay will look like though.