People who have no credentials, but lots of talent, sometimes start their own business. This is something I used to comment on a lot on homeschooling lists. The two examples I typically gave back then were: Bill Gates is a college dropout and Madonna is a college dropout.
An example that might mean a bit more to you: In this forum, IIRC, jacquesm is a high school dropout. He is currently #3 on the leaderboard. If you haven't read his blog, you might find it of interest: