1. Play by the "rules": stockpile the degrees, certifications, awards, etc. that we all know are largely useless but are absolute requirements for signaling your way through a standard corporate job interview. If you are after a normal, boring, corporate American desk job (nothing wrong with this depending on your life situation) you must play the game by the rules. If you don't, you will delude yourself and lose opportunities to lesser talented candidates who are better at playing the game.
2. Leverage your connections: use your professional connections to bypass / skip many of the requirements set by the "rules" to get a job. This requires less of playing by the rules but means you must have a solid professional network of people that have good jobs at companies that are looking to hire and are impressed enough by your work to give you a recommendation. This is harder than it seems, even for those with good connections, but I personally have found the most success finding good jobs these way.
3. Set your own rules: start your own business. This is the toughest but allows you to completely skip the rules. It also requires the greatest amount of talent and offers the greatest amount of reward. Speaking from personal experience, however, unless you have stockpiled savings and have excellent work ethic, this is a massive risk that has the potential to destroy your savings, emotional state and family relationships.
If I were you, I'd focus on a combination of #1 and #2. Get the college degree even if you think it's useless -- I'm sure you're being rejected immediately because of a lack of college degree. If you really don't want to do that, start working your professional network for referrals or start working on a great side project that you can present at an interview that showcases your talents and makes up for your lack of degrees. #3 is the dream, of course, but I've found that there is enormous value in the stability of a regular paycheck and insurance, especially when you have dependents, despite the soul-crushing nature of corporate jobs.
Good luck.