Laser pointers don't work if the video is being recorded or screencast at the same time. They only work when the viewer is in the same room, and even then, they are typically pretty poor.

Out of several dozen different uses of laser pointers, I've only ever been able to (easily) see perhaps 3 or 4 of them, plus another small portion if focusing entirely on the game of spot-the-laser-pointer. It's related to my colourblindness.

As such, verbal cues (or a long stick) are preferable to a laser pointer. Of course, use a laser pointer to assist those who can see it, but it's better assume half the people in the room can't and use words to this effect.

This also applies to comments within the presentation, not just the verbal part of the presentation.