I normalized all the keyboard shortcuts using several methods, the most important one is to switch Cmd and Ctrl keys. I documented that here: http://mntmn.com/Hipster%20Linux#keyboard-cmd-ctrl-copypaste...
I use Terminator for Terminal and set up Ctrl-C und Ctrl-V for copy and paste shortcuts. Terminator will smartly handle Ctrl-C as a signal when there is no selection.
I use XFCE with a custom HiDPI theme and app switcher works with Cmd-Tab. I bound Cmd-Space to Application Finder which gives me a Spotlight-like launching experience. For fulltext search I can recommend recoll.
I use Ergoemacs which gives me CUA-like shortcuts in Emacs, too.
Feel free to drop me an email (lukas at mnt dot mn) if you need more tips. Almost everything can be made to work.