> Designing new viruses or bacteria for a neo-plauge is less likely
Humankind has been genetically engineering organisms for most of our existence. Corn originally looked like grass. Chickens were lean, tough, and could fly. Dogs have been transformed from generalist survivors into purpose-built machines breed for beauty, farm work, and everything in between. The avocado, of all things, is a fantastic example of how capable we are at creating something which shouldn't really exist.
Doing the same with bacteria isn't that much harder, if you've got time and a few basic tools. Our manipulation of the genes directly only makes the process faster.