That's not the profound part.
> The application of this simple formula tends to arrive at a blindingly obvious conclusion: first build the features that affect lots of users as profoundly as possible, and which you can build quickly and cheaply.
The profound part is the ending of that sentence -- "and which you can build quickly and cheaply."
I know a huge number of startups (probably the overwhelming majority of them, actually) that think "we're going to do things right" instead of thinking "what's the next feature that will get us the biggest bang for least buck". Most new founders skip past the denominator in Geoff's equation, which later turns out to be the achilles heel that kills most startups.
Of course the fine grained level of decision making is very hard too, but you have to learn to walk before you learn to run.