The article is interesting, but the conclusion that all antidepressants on the market are flawed is not correct, mostly because different antidepressants target different systems in different ways. I took Celexa for over a year, it worked OK but not great, and then after reading the wikipedia article on treatment of depression, I tried SAM-e, which works much better (200mg Jarrows in the morning with a B-complex supplement to break down the homocysteine). Prior to Celexa, I tried Zoloft, which was completely useless.