We've been suffering this for ages in Iran. But in retrospect, it has been a blessing more than a curse. For example, until a year ago, Android Market and later Play Store were unavailable in Iran. Even now, many (most?) popular apps are unavailable for Iranians, e.g Facebook, Messenger, etc. This has given rise to a series of new start-ups, aiming to fill the void left by major multinational corporations. Right now more than 90% of the smartphones in Iran are android-based and most people have Cafe Bazaar (Play Store alternative) installed on their phones. The same thing with Amazon and Digikala.
It's not as good for the consumers, but it has made it a very good time to be an entrepreneur in Iran. I wonder if it was not for all the sanctions and censorship, would we have what we have now.
But as I said it on HN elsewhere[1], please stop using App Engine for your projects. Simplenote, Udacity, etc. have been inaccessible to Iranians not because they chose to, but because they use Google as their hosting platform.