Unfortunately this was my first thought as well. Although wxwidgets works on several platforms, it manages to look and feel alien on almost every. If you care about usability, I believe your application should be consistent with the rest on the target platform(s). Wxwidgets based applications are simply failures especially on Windows.

QT fares significantly better on the usability. Java's look and feel system works as well. You could also separate the V properly, and for instance use WinAPI wrapper on Windows platform. Just please, please let wxwidgets die already :(

Mostly because I've always used wxpython for my python 2.7 projects.

I'm doing some reading about PyQt5 now and I think I'll give it a shot.

Thanks for the reply.