React Native is very different than other approaches because:
1. We're not promising to give you One Weird Trick that allows you to change nothing about your development philosophy/practices and yet automatically create excellent mobile experiences. If you're developing for mobile, and you want an excellent user experience, you must care about performance and you must care about programming nuanced interactions. Behind any great mobile experience, is someone who cared. Don't believe anyone that tells you differently. However, I feel that the amount of work that React Native asks of developers in order to achieve it, is much less than any other alternative that I've seen.
2. React Native doesn't use the DOM at all. React naturally tames many of the performance issues that typically arise from unpredictable programming practices in the browser, but that can only get you so far. React Native takes it to the next level, beyond what can be done in the browser. React Native shows that ReactJS has always been more about "zero DOM" than "virtual DOM" (contrary to popular belief).
4. React Native is different because we want to keep some of the best parts about web development. Just because we want the performance and resource control of native views, that doesn't mean we should abandon the great things about the web. With React Native, you can use CSS FlexBox to lay out your native views, and many other familiar style attributes - but without the catastrophic CSS style reflows. The event system also works exactly as it does in your React apps today because it runs the same library code. By building in terms of the subset of web styles/layout that we know we can make fast native implementations for, it allows developers to build great apps today without setting back progress of the web in the future. I feel this is strictly better than encouraging developers to abandon anything remotely resembling web technology and instead learn a completely different toolchain (or two or three).
3. React Native is different because it makes high quality apps written in JS possible. With browsers, you will likely run up against a fundamental limitation and there's nothing you can do about it. Either you don't have access to a platform component (certain scroll view with physics/Maps), or the interaction that you're implementing keeps getting interrupted by image decoding and there's nothing you can do about it.
With React Native, you can do something about it. You can build ReactJS apps using native platform views that could never be implemented in JS (like Maps), and you can also build using higher performing granular building blocks (multi-threaded decoded <Image />) (<View/> blocks that don't use the DOM at all). The result is that this unlocks an unprecedented level of quality that feels great and matches the platform characteristics.