Seems like a pretty good use case for lasers as you can generally hit only what your aiming out, and you don't have any explosive and/or metal shrapnel falling back down into populated areas.
For that reason, I think the ideal solution would involve capturing the drone somehow, maybe with a net of some kind. Innocent drones could be marked with contact information, allowing them to be returned to their owner in the event that they are mistakenly captured.
As an added benefit, harmlessly capturing the drone would provide more useful evidence for the police investigating drug crimes.
But most modern AA weapons have tremendous velocities and are often explosive. Even after losses due to air resistance, AA shrapnel can come with with lethal velocities. I was told by somebody I trust that the Baghdad suffered more damage in financial terms from AA fallout than the actual US air strikes in the first US/Iraq war.