A tip if you already use lifecycle programs: Set up your marketing automation tool to automatically unsubscribe your recipients from the program, if they are not opening the first 2-3 emails (thereby showing a lack of interest in the specific program). This allows you to keep a higher percentage of email permissions, which you can use for less frequent communication.

Otherwise a large part of the uninterested segment will end up revoking their email permission, i.e. Unsubscribing from your permission base entirely.